High-Temperature Requirement A Serine Peptidase 1

A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).

Also Known As:

Serine Protease HTRA1; HTRA1, Serine Protease; High Temperature Requirement A Serine Peptidase 1; Protease HTRA1, Serine

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Serine Proteases: 3808
        Serine Endopeptidases: 11
        High-Temperature Requirement A Serine Peptidase 1: 64
      - Endopeptidases: 643
        Serine Endopeptidases: 11
        High-Temperature Requirement A Serine Peptidase 1: 64

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